Table 4. Correlation Between Maternal Gestational Interleukin-6 (IL-6) Concentration and Age-Corrected Offspring Regional Fractional Anisotropy (FA) in Early Life.

Average maternal IL-6 concentration during pregnancy was negatively associated with age-corrected FA bi-laterally in the newborn Uncinate Fasciculus (UF). Maternal gestational IL-6 concentration and UF FA at 12-mo age were not significantly associated. However, elevated maternal gestational IL-6 concentration was associated with accelerated UF FA increase during the 12-mos of life.

Dep. Var.	Fiber Tract	Age Assessment	r [95% CI]	p-statistic
FA (N=86)	L UF ROI	Newborn	-0.32 [−0.5 −0.1]	0.004**
	R UF ROI	Newborn	-0.34 [−0.52 −0.13]	0.002**
FA (N=32)	L UF ROI	12-mo	0.09 [−0.27 0.42]	0.643
	R UF ROI	12-mo	0.03 [−0.32 0.37]	0.875
FA (N=32)	L UF ROI	12-mo Change	0.42 [0.09 0.67]	0.013*
	R UF ROI	12-mo Change	0.47 [0.14 0.7]	0.007**