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. Author manuscript; available in PMC: 2019 Nov 1.
Published in final edited form as: Clin Immunol. 2018 Apr 11;196:97–102. doi: 10.1016/j.clim.2018.04.003

Figure 3. Peroxynitrite and low methionine concentrations synergize to increase CD70 and KIR expression.

Figure 3

Peroxynitrite-treated CD4+ T cells were cultured in media containing low methionine concentrations then effects on CD70 and KIR expression were measured by flow cytometry. (A) CD70 (p<0.001 for overall Met effect; p<0.001 for overall peroxynitrite effect; n=6) and (B) KIR (p<0.001 for overall folate effect; p<0.01 for overall peroxynitrite effect; n=5). Repeated measures ANOVA was used to analyze relationship between methionine and peroxynitrite concentrations. Methionine and peroxynitrite concentration plus their interaction was included as the within-subjects effects. Post-hoc tests with Bonferroni correction for multiple comparisons were used to examine specific effects at each given concentration. Error bars represent SEM.