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. 2018 Oct 11;8:15138. doi: 10.1038/s41598-018-33463-2

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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(a) Achieved sampling of the acquisition parameter space with conventional methods and ZEBRA. (b) CRLB results for b-values between 0 and 3000, sampled at 250 mm⁻² s and $N_{i} = 1, .., 10$ with overlayed contour lines. (c) Results from adult experiment E2. The obtained T1 values for white matter, grey matter and cerebro spinal fluid are shown for interleaved setting between $N_{i} = 1, .., 10$ .