Table 1.
Logistic regression analysis of VEGFA SNPs in probands and control subjects
| Genotype | Allele | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| N (%) | OR | 95% CI | p value | Adj p value | N (%) | OR | 95% CI | p value | Adj p value | p of HWEa | ||||
| rs699947 | GG | GT | TT | GG | T- | |||||||||
| Controls | 40 (35) | 49 (43) | 26 (22) | 0.89 | 0.56–1.43 | 40 (35) | 75 (65) | 0.15 | ||||||
| Probands | 169 (38) | 185 (41) | 92 (21) | 0.84 | 0.48–1.46 | 0.80 | 0.79 | 169 (38) | 277 (62) | 0.87 | 0.57–1.34 | 0.54 | 0.56 | |
| rs833070 | GG | AG | AA | GG | A- | |||||||||
| Controls | 37 (29) | 64 (51) | 25 (20) | 0.67 | 0.43–1.05 | 37 (29) | 89 (71) | 0.78 | ||||||
| Probands | 176 (37) | 204 (42) | 99 (21) | 0.83 | 0.47–1.46 | 0.21 | 0.23 | 176 (37) | 303 (63) | 0.72 | 0.47–1.10 | 0.12 | 0.12 | |
| rs2146323 | CC | AC | AA | CC | A- | |||||||||
| Controls | 47 (40) | 64 (54) | 7 (6) | 0.56 | 0.37–0.85 | 47 (40) | 71 (60) | 0.01 | ||||||
| Probands | 242 (51) | 184 (38) | 53 (11) | 1.47 | 0.63–3.43 | 0.005* | 0.007* | 242 (51) | 237 (49) | 0.65 | 0.43–0.98 | 0.037 | 0.042 | |
VEGFA vascular endothelial growth factor A, SNP single nucleotide polymorphism, N number, OR odds ratio, CI confidence interval, HWE Hardy–Weinberg Equilibrium
*Survived Bonferroni correction; Adj p value covaried for age, sex, race
aHWE test was carried out in controls
The bolded values stand for signficant uncorreted p values (p < 0.05)