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. 2018 Oct 11;8:15178. doi: 10.1038/s41598-018-33433-8

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Comparison of z-scores expressing the observed numbers of occurrences of pentapeptides in relation to the expected numbers of occurrences (see Methods, “Analysis of pentapeptide abundances using permutation groups and z-scores” section) for domain (DM) and non-domain (ND + NN) regions. The z_norm notation points out that normal distribution is assumed. Every point represents a pentapeptide. Colouring by abundance (A) or by hydrophobicity scale (B)³³. Arithmetic average is taken when two points overlap. In Fig. 2A, red means many overlapping pentapeptides, blue - single pentapeptides.