Table 2.

Examples of known, biologically relevant sequence motifs found in overrepresented outlier pentapeptides.

Sequence motif	Motif function	Number of high-abundance outliers in DM	Number of high-abundance outliers in ND	Number of high-abundance outliers in NN
[HY]RD	protein kinase active site34	56	23	14
HExxH	zinc metallo-protease active site19,35	41	8	37
G[ST]GK	ATP-binding motif, P-loop-like34	18	2	8
CxxC	Zn-binding motif in zinc fingers or oxido-reductase active site36,37	1587	680	1085