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. 2018 Oct 11;9:4216. doi: 10.1038/s41467-018-06469-7

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Gene expression profile and functional analysis of the transplanted iSG. a Principal component analysis based on RNA-seq. The data are shown for iSGs on d23, transplanted iSGs, transplanted iSG with mesenchyme, ESCs, SMG at E13.5, E15.5, E18.5, and 6 weeks. The blue circle outline indicates transplanted iSGs with or without mesenchyme. b Time-course of the amount of saliva secretion in major salivary glands-defective mice (square) and combined iSG transplanted major salivary glands-defective mice (circle), every 1 min for 15 min after intraperitoneal injection of pilocarpine; n = 8 mice (iSG-transplanted); n = 4 mice (major salivary gland defect). *P < 0.05, **P < 0.001. c Assessment of the amount of saliva secretion in combined iSG-transplanted major salivary glands-defective mice for 8 min after water or gustatory (citric acid) stimulation; n = 4 mice (each group). *P = 0.034. d Venn diagram illustrating the proteins between iSG-derived saliva and whole saliva. n = 3 mice (each group). The results are presented as the mean ± S.D. Statistical analyses were performed using Student’s t-test

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