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. 2018 Oct 11;8:15175. doi: 10.1038/s41598-018-33290-5

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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SHLP2 prevents loss of mitochondria. (A) Representative confocal images showing: (1) Relatively abundant mtGFP staining in normal (NL) untreated (UN) (top left panel) and NL SHLP2-treated (top right panel) cybrid cells, and (2) drastic increase in mtGFP staining in SHLP2-treated AMD cybrids (lower right panel) compared to AMD UN cybrids (lower left panel). Scale bar equals 50 µm; Green color represents mitochondrial GFP (mtGFP); Blue color represents DAPI (nuclear stain)). (B) Quantitation of the images showed that SHLP2 increased mtGFP fluorescence by 153.02% (P < 0.05, n = 4–5) in the cytoplasm of AMD cybrid cells. All mtGFP fluorescence intensities within a group were normalized to DAPI. Data are presented as Mean ± SEM and normalized to untreated normal cybrids which were assigned a value of 1. Experiments were performed at the 72 hr time-point.