Table 2. Summary of studies reported outcomes of ALPPS vs. TSH.
| Type of study | Ratti et al., 2015 (42) | Adam et al., 2016 (4) | Sandström et al., 2018 (43) | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Retrospective, case-matched | Retrospective, case-matched | RCT | |||||||||
| ALPPS | TSH | P | ALPPS | TSH | P | ALPPS | TSH | P | |||
| No. of cases | 12 | 36 | 17 | 41 | 48 | 49 | |||||
| Increase in FLR vol. (%) | 47 | 41 | NS | NR | NR | 68 | 36 | <0.0001 | |||
| Median interval (days) | 11 | 31 | 0.024 | 12 | 103 | <0.001 | 11 | 43 | <0.0001 | ||
| Morbidity (no.) | 10 | 13 | 0.011 | 7 | 16 | 0.99 | 19/44 | 12/28 | 0.99 | ||
| 90-day mortality | NR | NR | 0 | 2 | 0.89 | 4 | 3 | 0.68 | |||
| Median follow-up | 12 | 37 | 20 | 30 | |||||||
| Recurrence | NR | NR | 8 | 17 | 0.28 | ||||||
| Overall survival | 92 | 94 | NR | 42 | 77 | 0.006 | |||||
ALPPS, associating liver partition and portal vein ligation in staged hepatectomy; TSH, two-stage hepatectomy; NR, not report; RCT, randomized clinical trial.