Table 2. Comparison of surgical treatments for hepatocellular carcinoma: resection versus liver transplantation experiences.
| Authors, publication year | Type of surgery | No. patients | Age (years) | Prior resection | Concomitant liver chronic disease | Milan criteria (in/out) |
Multiple hepatic lesions | Extrahepatic tumor | Neoadjuvant chemotherapy | Adjuvant chemotherapy | Type of donor | Follow-up (years) | Recurrence | Survival rate (%) | Outcomes |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Ismail et al., 2009 (49) | Resection | 8 | 9.9±5.2 | – | 5 (63%) | 0 in/8 out | 4 | 5 | 4 | 8 | – | 4 | 6 (75%) | 50 | 4 alive, 4 dead |
| LT | 11 | 9.9±5.2 | 2 | 5 (45%) | 3 in/8 out | 5 | 4 | 6 | 5 | 8 deceased, 3 living | 4 | 1 (9.1%) | 72 | 8 alive, 3 dead (1 recurrence, 1 MOF, 1 chronic rejection + HCV recurrence) | |
| Malek et al., 2010 (21) | Resection | 5 | 12.3 (5.6–15.8) | – | NA | NA | NA | NA | 5 | 5 | – | 10 | 1 (20%) | NA | NA |
| LT | 2 | 12.3 (5.6–15.8) | 1 | NA | NA | NA | NA | 2 | 2 | NA | 10 | 0 (0%) | NA | NA | |
| McAteer et al., 2013 (20) | Resection | 60 | 14.6±4.1 | – | NA | NA | 12 (20%) | 13 | NA | NA | – | 5 | NA | 53.4 | 32 alive, 28 (46.7%) dead |
| LT | 20 | 10.7±6.2 | NA | NA | NA | 10 (50%) | 2 | NA | NA | NA | 5 | NA | 85.3 | 17 alive, 3 (15%) dead |
§, Milan criteria are defined according to Mazzaferro et al. (14). HCV, hepatitis C virus; MOF, multi-organ failure; NA, not available; LT, liver transplantation.