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. 2018 Oct 5;9:2314. doi: 10.3389/fimmu.2018.02314

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Copyright © 2018 Fekete, Bencze, Szabo, Csoma, Biro, Bacsi and Pazmandi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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NLRX1 but not NLRC5 controls the RIG-I/MDA5 agonist-induced type I IFN and pro-inflammatory responses in human moDCs. (A–D) moDCs transfected with the indicated siRNAs were stimulated with the RIG-I/MDA5 ligand polyI:C (1 μg/ml). The protein levels of IFN-α, IFN-β (A), TNF, IL-6, and IL-8 (B) were detected by ELISA after 24 h. (C,D) Kinetics of IκBα degradation was determined by western blotting. (C) A representative blot is shown. (D) Bar graphs show the relative density of IκBα measured at 60 min of stimulation. (A,B,D) Data are shown as mean ± SD from 4 independent experiments and analyzed using one-way ANOVA followed by Bonferroni's post-hoc test. ^**p < 0.01, ^***p < 0.01 ^****p < 0.0001 vs. untreated; ^#p < 0.05, ^##p < 0.01, ^####p < 0.0001, n.d., not determined.