Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Model for primer processing at OriL. RNase H1 cuts the RNA primer but leaves 1–3 ribonucleotides at the RNA:DNA junction. POLγ fills the gap and continues to synthesize a few nucleotides into the duplex region, creating a short 5′-flap containing the RNA. FEN1 or a FEN1-like activity cleaves the short RNA flaps and DNA ligase III can ligate the DNA.
