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. 2018 Jul 17;46(18):9667–9683. doi: 10.1093/nar/gky600

Figure 1.

Figure 1.

tRNA acceptor-stem bases considered in the analysis of aaRS groove recognition. Pyrimidines are colored with primary colors, purines with their respective complements. Cubes adjacent to each tRNA represent the availability of aaRS•tRNA co-crystals showing productive acceptor-stem interactions in prokaryotes (open) or other (gray) organisms. The width of the circle for each discriminator base indicates its strength as compiled by Giegé and Eriani (50). Note the following idiosyncratic features: (i) tRNALeu, tRNAPhe, tRNAThr and tRNAHis have identical bases in all four positions; (ii) tRNAAsp and tRNASer similarly share identical signatures; (iii) tRNAHis has a unique extra G at position –1; (iv) tRNAIle has a completely ambiguous first base pair.