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. 2018 Sep 18;41(9):868–880. doi: 10.14348/molcells.2018.0109

Fig. 2. miR-139-5p is negatively regulated by EZH2 by increased expression of H3K27me3, which is validated by RT-qPCR and ChIP.

Fig. 2

(A) The results of RT-qPCR and ChIP reveal that miR-139-5p is regulated by H3K27me3; (B) Over-expressed EZH2 functions to promote the protein expression of H3K27me3; (C) The statistical analysis for the effect of EZH2 on the protein expression of H3K27me3; *p < 0.05, vs. the NC group; NC, negative control; miR-139-5p, microRNA-139-5p; EZH2, enhancer of zeste homolog 2; RT-qPCR, reverse transcription quantitative polymerase chain reaction; ChIP, chromatin immunoprecipitation.