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. 2018 Sep 18;41(9):868–880. doi: 10.14348/molcells.2018.0109

Fig. 3. Down-regulated expression of EZH2 and up-regulated expression of miR-139-5p suppresses EMT in PC cells.

Fig. 3

RT-qPCR (A) and Western blot analysis (B, C) are employed to determine the expression of miR-139-5p, EZH2, N-cadherin, Vimentin and E-cadherin. Down-regulated EZH2 expression and up-regulated expression of miR-139-5p enhance gene expressions of epithelial lineage-related marker (E-cadherin) and suppress those of mesenchymal cells-related markers (N-cadherin and Vimentin). *p < 0.05, vs. the blank and NC group; n = 3; the measurement data are analyzed by t-test; PC, pancreatic cancer, miR-139-5p, microRNA-139-5p; EZH2, enhancer of zeste homolog 2; EMT, epithelial-mesenchymal transition.