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. 2018 Sep 11;75(22):4177–4185. doi: 10.1007/s00018-018-2913-x

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© The Author(s) 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 1 — Regulation of microtubule nucleation by integrins. The integrin-dependent activation of SRC and ERK regulates microtubule (MT) nucleation at least in part by regulating the localization of γ-tubulin to the centrosome. γ-TuRC is assembled in the cytoplasm where it associates with additional proteins that regulate its centrosomal localization and microtubule nucleating ability. The integrin regulation of microtubule nucleation through SRC–ERK signaling could be due to integrin regulation of the assembly of the γ-TuRC complex, the association of this complex with NEDD1, CDK5RAP2 or MOZART (MZT) or the binding of the complex to the centrosome (dashed arrows). PM plasma membrane