Table 4.

Treatment-related features

Reference	Radiotherapy					Induction chemotherapy			Concurrent chemotherapy
	Number of patients		Regimena	Dose (Gy)		Number of patients	Type of chemotherapy	No. of cycles (median)	Number of patients	Type of chemotherapy	No. of cycles (median)
	3DCRT	IMRT		Total (median)	Per fraction
[18]	32	30	Conventional	70	2	20	Docetaxel/cisplatin	ns	35	Cisplatin 40 mg/m2 every 7 days	6
[19]	0	26	Conventional	70	1.8	0	Not administered	0	26	Cetuximab	ns
[20]	0	122	Conventional	70	2	0	Not administered	0	122	Cisplatin 100 mg/m2 every 21 days	ns
[21]	0	51	Conventional	70	ns	0	Not administered	0	51	Cisplatin 100 mg/m2 every 21 days	ns
[22]	ns	ns	Conventional	72	2	0	Not administered	0	44	Cisplatin 100 mg/m2 every 21 days	ns
[23]	ns	ns	Conventional	72	2	0	Not administered	0	68	Cisplatin 100 mg/m2 every 21 days	ns
[24]	0	88	Conventional	70	2	0	Not administered	0	74	Cisplatin + 5-fluorouracil	ns
[25]	0	70	Conventional	66	1.8	0	Not administered	0	70	Cisplatin 100 mg/m2 every 21 days	ns
[26]	ns	ns	Conventional	70	2	0	Not administered	0	70	Other	ns
[27]	0	108	Conventional	70	2	48	Docetaxel/cisplatin	2	44	Cisplatin + 5-fluorouracil	6
[28]	0	75	Conventional	70	2	0	TPF	1	75	Cisplatin 100 mg/m2 every 21 days	ns
[29]	ns	ns	ns	ns	ns	0	Not administered	ns	ns	ns	ns
[30]	40	0	Conventional	70	2	0	Not administered	0	35	Cisplatin 30 mg/m2 every 7 days	ns
[31]	0	69	Conventional	70	2	15	ns	ns	46	Cisplatin 40 mg/m2 every 7 days	ns
[32]	0	72	Conventional	70	2	15	ns	ns	40	Cisplatin 30 mg/m2 every 7 days	6
[34]	ns	ns	Conventional	66	2	0	Not administered	0	85	Other	6
[35]	5	42	Conventional	66	2	0	Not administered	0	47	Cisplatin + 5-fluorouracil	ns
[36]	0	86	Conventional	72	2	0	Not administered	0	86	Other	ns
[37]	ns	ns	Conventional	70	2	0	Not administered	0	47	Cisplatin + 5-fluorouracil	ns
[38]	0	287	Conventional	66	2	26	ns	ns	86	Other	ns
[39]	0	100	Accelerated	69.96	2.12	0	Not administered	0	100	Cisplatin 100 mg/m2 every 21 days	ns
[40]	ns	ns	ns	ns	ns	0	Not administered	0	74	Cisplatin 100 mg/m2 every 21 days	ns
[42]	0	125	Conventional	70	2	0	Not administered	0	125	Cisplatin 100 mg/m2 every 21 days	ns
[43]	0	40	Conventional	70.2	1.8	40	Docetaxel/cisplatin	3	36	Cisplatin 100 mg/m2 every 21 days	ns
[44]	0	76	Conventional	72	2	0	Not administered	0	76	Cisplatin 100 mg/m2 every 21 days	ns

ns not stated, 3DCRT 3-D conformal radiotherapy, IMRT intensity-modulated radiotherapy, TPF docetaxel, cisplatin, 5-fluorouracil

^aConventional: conventional once-daily fractionation. Accelerated: accelerated fractionation