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. 2018 Jul 6;45(12):2190–2200. doi: 10.1007/s00259-018-4078-0

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© The Author(s) 2018

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 1 — Progression from healthy arteries to complicated lesions. FDG and NaF uptake have long been known to precede vascular calcification evident on CT and intravascular ultrasonography (IVUS) [5, 6]. The paradigm shift is the stronger predictive power of NaF uptake and the occurrence of active calcification measured by ¹⁸F-NaF uptake in early coronary fatty streaks and preatheroma (CAC coronary artery calcium)