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. 2018 Aug 30;38(10):945–954. doi: 10.1007/s40261-018-0687-4

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© The Author(s) 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 6 — Correlation between the change in QTc interval (QTcF) and corrected calcium concentration in the single-dose study (a) and the multiple-dose study (b). Regression equation in the single-dose study: change from baseline in QTcF = 115.70–13.31 * corrected calcium. 90% confidence interval for coefficient of corrected calcium: − 15.10 to − 11.51. Regression equation in the multiple-dose study: change from baseline in QTcF = 108.73–11.91 * corrected calcium. 90% confidence interval for coefficient of corrected calcium: − 14.77 to − 9.04