Table 1.
Subject demographics (single- and multiple-dose studies)
| Characteristic | Single-dose study | Multiple-dose study | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Placebo | 1 mg | 3 mg | 6 mg | 12 mg | 20 mg | Placebo | 6 mg | 12 mg | |
| n | 12 | 6 | 6 | 6 | 6 | 6 | 6 | 6 | 6 |
| Age |
23.7 (20, 28) |
22.3 (21, 25) |
23.3 (20, 27) |
22.3 (20, 28) |
20.8 (20, 24) |
28.5 (20, 35) |
23.8 (20, 29) |
23.5 (20, 36) |
23.5 (20, 32) |
| BMI |
20.7 (18.8, 23.6) |
21.8 (18.9, 24.5) |
20.8 (19.0, 23.2) |
21.1 (19.0, 23.0) |
21.9 (18.6, 24.6) |
22.8 (21.1, 23.7) |
21.8 (18.6, 24.0) |
21.1 (19.8, 22.3) |
21.9 (19.5, 23.7) |
| Intact PTH (pg/mL) |
37.6 (25, 52) |
32.2 (22, 41) |
37.2 (31, 46) |
34.2 (17, 47) |
36.3 (30, 43) |
34.0 (23, 46) |
33.8 (25, 42) |
29.0 (24, 37) |
31.0 (25, 42) |
| Corrected calcium (mg/dL) |
9.12 (8.8, 9.4) |
9.33 (9.1, 9.6) |
9.08 (8.9, 9.3) |
9.08 (8.8, 9.4) |
9.10 (9.0, 9.4) |
9.17 (9.0, 9.4) |
9.13 (8.8, 9.5) |
9.03 (8.8, 9.3) |
9.13 (8.9, 9.4) |
| Phosphorus (mg/dL) |
4.08 (3.4, 4.6) |
4.18 (3.8, 4.9) |
4.30 (4.1, 4.7) |
3.98 (3.6, 4.2) |
4.05 (3.9, 4.3) |
3.92 (3.4, 4.5) |
4.23 (3.8, 4.7) |
4.12 (3.5, 4.7) |
4.55 (4.1, 5.0) |
Data are the mean (minimum, maximum)
BMI body mass index, PTH parathyroid hormone