Table 2.

Polygenic risk scores

	PRS category	Controls	CRC	Expected events	HR	p for HR
PRS1	Median (IQR)	− 0.12 (− 0.48 to 0.30)	− 0.03 (− 0.39 to 0.40)
	First quartile	84	22	28	Ref	0.41
	Second and third quartile	167	54	52	1.33 (0.76–2.33)	0.31
	Fourth quartile	84	33	28	1.50 (0.82–2.72)	0.19
PRS2	Median (IQR)	0.30 (− 0.057 to 0.55)	0.51 (0.068–0.75)
	First quartile	84	18	26	Ref	< 0.0001
	Second and third quartile	165	38	53	1.05 (0.59–1.89)	0.86
	Fourth quartile	84	53	30	2.62 (1.49–4.60)	0.001

PRS polygenic risk score, IQR interquartile range

PRS1 Weighted on odds ratios from general population, i.e. in sporadic CRC cases

PRS2 Weighted on hazard ratios from this study

Log rank survival curves PRS1: p = 0.32

Log rank survival curves PRS2: p < 0.0001