Fig. 7.

Tetanus toxoid protein—used in glycoconjugate vaccines to help stimulate T-cell-mediated long-lasting responses. a Sedimentation coefficient distribution from SEDFIT analysis for seven loading concentrations showing ∼ 14% of dimer, b prolate ellipsoid representation using ELLIPS1 analysis for monomeric tetanus toxoid protein showing an asymmetric structure of axial ratio ∼ 3. The slightly elongated structure facilitates the conjugation with polysaccharide chains. From Abdelhameed et al. (2012) and reproduced with permission from Elsevier