Table 2.
The subthreshold doses of LSP4-2022 and VU152100 administered in each test
| Test | LSP4-2022 | VU152100 |
|---|---|---|
| MK-801-induced hyperactivity | 0.1 mg/kg | 5 mg/kg |
| DOI-induced head twitches | 0.5 mg/kg | 1 mg/kg |
| Modified forced swim test | 0.1 mg/kg | 0.1 mg/kg |
| Social interaction | 0.1 and 0.5 mg/kg | 2 and 5 mg/kg |
| Novel object recognition | 1 mg/kg | 0.25 mg/kg |
| Amphetamine-induced hyperactivity and PET studies (rats) | 0.1 mg/kg | 5 mg/kg |