Fig. 9.

The HIF-1a/Beclin1 signaling pathway is involved in regulating the protective effect of HPC against OGD/R-induced injury. a Summary of the mean cell viability determined by MTT under the indicated conditions. b Effect of Beclin1 knockdown on the protective effect of HPC. Summary of the mean cell viability determined by MTT, from three independent experiments using six wells of cells in each experiment. Data are shown as the mean ± SD. *P < 0.05, and **P < 0.01 vs. control group; ^#P < 0.05, and ^##P < 0.01 vs. OGD/R group; ^△P < 0.05, and ^△△P < 0.01 vs. HPC + OGD/R group of negative control (NC) cells