Fig. 3.

Indeterminate findings on prostate-specific membrane antigen (PSMA)-targeted positron emission tomography (PET)/computed tomography (CT). A 62-year-old man with history of biochemical recurrence undergoing [¹⁸F]-DCFPyL PET/CT. a Whole-body maximum intensity projection image demonstrates multiple foci of radiotracer uptake (red arrowhead and arrow). b Axial CT, c axial PET, and d axial PET/CT demonstrate intense radiotracer in a thyroid nodule (red arrowheads), which was classified as PSMA-RADS-3C and further workup (biopsy) was recommended. Subsequent biopsy yielded papillary thyroid carcinoma. e Axial CT, f axial PET, and g axial PET/CT show focal, intense radiotracer uptake in the spleen (red arrows). This was classified by an experienced reader as a likely inflammatory finding that was not suspicious for either prostate cancer or another malignancy and was labeled as PSMA-RADS-2. The overall scan score for this patient was, therefore, PSMA-RADS-3C