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. 2018 Sep 5;265(11):2625–2632. doi: 10.1007/s00415-018-9042-1

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© The Author(s) 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 3 — Binding curves of CSF samples from patients with NMDAR encephalitis. Normalized MFI signals (± SEM) show concentration-dependent binding of human CSF samples to NR1 protein (a). None of the binding curves reached their MFI_max plateau, indicating that CSF NR1 antibody concentrations were clearly below the saturation of the NR1 epitopes and that the binding constant c₅₀ cannot be calculated in these samples. The MFI did not correlate in this small patient cohort with patient age (b), modified Rankin scale at the time of CSF analysis (c) and the duration of the hospital stay (d)