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. 2018 Jun 25;45(5):663–677. doi: 10.1007/s10928-018-9597-6

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© The Author(s) 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 4 — The ratio of predicted to observed dose metrics: AUC for time-concentration profile of AT (red dots), AUC for time-concentration profile of NT (blue dots), C_max for AT (green dots). Two-fold margin is marked in pink (Color figure online)