Fig. 1.

Genotype and bleomycin-induced lung phenotype of C57BL/6J, C3H/HeJ, and Blmpf1 subcongenic mice. a Genotypes [C3H/HeJ alleles (white box); C57BL/6J alleles (black box); undetermined (gray box)] were assessed with microsatellite and SNP markers. b Mice were treated with bleomycin by osmotic minipump and euthanized 42 days later. The percentage of the lung with fibrosis was measured from image analysis of histological sections and the mean ± SEM of 4–17 bleomycin-treated mice for each subcongenic line, as indicated below figure, and for the parental strains, is given. Representative lung sections stained with Masson’s trichrome; magnification ×50. No fibrosis was detected in untreated control animals