Table 1.
DNA sequence analysis of reduced Blmpf1 candidate genes
| Gene name | Symbol | Missense, stop or splice variantsa | Nonsense mediated decay or 3′, 5′ variantb | Upstream or downstream variantc | Associationd |
|---|---|---|---|---|---|
| Histocompatibility 2, class II antigen E beta2 | H2-Eb2 | 4 | 11 | 40 | 0.65 |
| Butyrophilin-like 2 | Btnl2 | 6 | 15 | 94 | 0.85 |
| Butyrophilin-like 1 | Btnl1 | 2 | 0 | 18 | 0.23 |
| Butyrophilin-like 4 | Btnl4 | 57 | 0 | 299 | 0.12 |
| Butyrophilin-like 6 | Btnl6 | 89 | 0 | 185 | 0.004 |
| Notch 4 | Notch4 | 8 | 153 | 6 | 0.002 |
| Tenascin XB | Tnxb | 29 | 1 | 51 | 0.02 |
| cDNA sequence BC051142 | BC051142 | 2 | 1 | 80 | 0.0003 |
| Pre B cell leukemia homeobox 2 | Pbx2 | 0 | 2 | 0 | No SNP |
| Advanced glycosylation end product-specific receptor | Ager | 1 | 1 | 1 | No SNP |
| FK506 binding protein-like | Fkbpl | 1 | 0 | 1 | 0.23 |
| Activating transcription factor 6 beta | Atf6b | 1 | 2 | 12 | 0.04 |
| Complement component 4B | C4b | 6 | 3 | 46 | No SNP |
| Complement component 4A | C4a | 3 | 0 | 54 | No SNP |
| Serine/threonine kinase 19 | Stk19 | 2 | 36 | 36 | No SNP |
| Ring finger protein 5 | Rnf5 | 1 | 0 | 0 | No SNP |
| Complement factor B | Cfb | 1 | 0 | 1 | 0.43 |
| Cytochrome P450, family 21, subfamily a, polypeptide 1 | Cyp21a1 | 12 | 3 | 113 | No SNP |
abcNumber of C3H/HeJ:C57BL/6J DNA sequence variants as categorized in Sanger database
dAssociation—minimal P value of association to pulmonary fibrosis in 23 inbred strains (Paun et al. 2013)