Table 4.

Results of the Disbenefit Analysis

	Male babies only screened		Both sexes screened
	Undiscounted	Discounted	Undiscounted	Discounted
Non CCALD X-ALD	8.61	8.61	8.61	8.61
Age of symptomatic presentation	35.00	20.55	35.00	20.55
Person years without diagnosis	301.34	176.95	301.34	176.95
Non X-ALD disorders	6.68	6.68	13.04	13.04
Age of symptomatic presentation	5.00	4.66	5.00	4.66
Person years without diagnosis	33.39	31.11	65.21	60.76
Number of cases of X-ALD in females	–	–	17.36	17.36
Age of symptomatic presentation	–	–	50.00	24.11
Person years without diagnosis	–	–	867.96	418.60
Total person years without diagnosis	334.73	208.06	1234.52	656.32
Total incremental QALYs from screening	280.15	82.42	279.78	82.30
Maximum QALY decrement per non CCALD case per year	0.84	0.40	0.23	0.13

– No cases in females when only male babies are screened