Figure 3: Effect of sequential rhFSH and hCG treatment on AMH and testosterone in patients with central hypogonadism.

Initial treatment with rhFSH for 30 days provoked an elevation of serum AMH, while testosterone remained at prepubertal levels. Shaded area represents normal AMH levels for boys with low testosterone (corresponding to pubertal Tanner stage one). Subsequent addition of hCG induced an elevation of T, which provoked a decline in serum AMH. Shaded area represents normal AMH values for Tanner stages 4–5, according to the T levels observed in the treated patients. *p<0.05; **p<0.01; ***p<0.001. AMH = anti-Müllerian hormone; hCG = human chorionic gonadotropin; rhFSH = recombinant human follicle-stimulating hormone; T = testosterone. Modified with permission from Young et al., 2005.¹⁰