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editorial
. 2018 Sep 10;14(2):15–17. doi: 10.17925/EE.2018.14.2.15

Table 1: Nephro-protective effect of gliclazide - postulated mechanisms.

  • Scavenging of reactive oxygen species

    • - by azabicyclo-octyl ring structure

    • - superoxide anion

    • - hydroxyl radicals

  • NAD (P) H oxidase suppression

  • Up-regulation of MnSOD

  • Enhanced NO availability (increased e NOs)

    • - ICAM-1 suppression

    • - Reduction of glomerular macrophage infiltration

e NOs = endothelial nitric oxide synthase; ICAM-1 intercellular adhesion molecule 1; MnSOD = manganese super oxide dismutase; NAD (P) H – nicotinamide adenine dinucleotide phosphate; NO = nitric oxide.