Figure 5.
Effect of Hypeon expression of TJs and MMPs in fibrillar Aβ1–42-treated bEnd.3 cells.
Results of western blot assay showed expression of MMP-2, MMP-9 and TJs (ZO-1, occludin and claudin-5). Equal amount of protein loading was confirmed by β-actin levels. Data are represented as mean ± SEM (one-way analysis of variance followed by Tukey's multiple comparison post hoc test). The experiment was conducted in triplicate. ##P < 0.01, vs. control group; *P < 0.05, **P < 0.01, vs. 20 µM Aβ1–42 group. Aβ1–42: Amyloid beta 1–42; Hyp: hyperoside; TJs: tight junction proteins; MMP: matrix metalloproteinase; ZO-1: zonula occludens-1.