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. Author manuscript; available in PMC: 2019 Oct 10.
Published in final edited form as: J Control Release. 2018 Aug 3;287:58–66. doi: 10.1016/j.jconrel.2018.08.002

Fig. 5.

Fig. 5.

In vivo siRNA-NP localization qualitatively decreased as the hydrogel degradability increased as visualized by MS fluorescent imaging. (A) Representative IVIS images of Cy5- siRNA/NP loaded hydrogels placed around femur fractures over time. (B) Quantification of siRNA/NP localization from IVIS imaging. Data showed the total radiant efficiency of drawn region of interest (ROI) in IVIS images normalized to day 0. Mean ± STDEV, N=6. (C) Rate constant (k’) and half-lives are derived from a one phase decay model.