Table 2.

Cost-analysis of RV vaccination and GE direct medical, non medical and indirect costs, in euro, for Health care and Social Perspective before and after universal RV vaccine introduction in Sicily.

	Before vaccination (2009–2012) n = 3,845 Costs in €		After vaccination (2013–2016) n = 2,026 Costs in €
	Total	Per year	Total	Per year	Cost saving in € per year
Vaccination Cost, Total (162,024 doses purchased)	0	0	6,805,008	1,559,481	+ 1,701,252
–vaccine cost (33.5 euro for single dose)	0	0	5,427,804	1,356,951	+ 1,356,951
–estimated vaccine administration cost (8.5 euro)	0	0	1,377,204	344,301	+ 344,301
Direct medical RVGE hospitalization costs for health care perspective (n. cases reported x HDR cost)	5,855,935	1,463,984	2,479,824	619,956	− 844,028
Estimated direct medical, non medical and indirect RVGE hospitalization costs for societal perspective	3,015,806	753,952	1,277,109	319,277	− 434,675
Estimated emergency room admission costs for health care and social perspective	7,517,433	1,879,358	3,183,472	795,868	− 1,083,490
Estimated primary care admissioncosts for health care and social perspective	3,284,886	821,222	1,392,429	348,107	−473,115
Total	19,674,060	4,918,516	15,137,842	3,784,460	− 1,134,056

^aMean pre vaccination HDR cost: 1,523 € vs Mean post vaccination HDR cost: 1,224 €.

^bHealth care RVGE hospitalization perspective x 0.515.

^cRVGE hospitalization observed x 2.69; total hospitalization cost x 0.315.

^dRVGE hospitalization observed x 2.42.