Table 1.
Global Burden of Disease 2016 estimates of the neglected tropical diseases (NTDs). Estimates are based on GBD 2016 Disease and Injury Incidence and Prevalence Collaborators.9
| Disease | Estimated Prevalence or Incidence | Vaccine under development? | Stage of development |
|---|---|---|---|
| Ascariasis | 799.683 million | Yes | Preclinical |
| Hookworm disease | 450.683 million | Yes | Phase 1 testing in endemic areas |
| Trichuriasis | 435.095 million | Yes | Preclinical |
| Schistosomiasis | 189.774 million | Yes | Phase 1 testing in endemic areas |
| Scabies | 146.785 million | Yes | Preclinical |
| Dengue | 101.064 million | Yes | Licensed vaccine and additional candidates in clinical development |
| Food-borne Trematodiases | 74.725 million | No | — |
| Lymphatic Filariasis | 29.382 million | No | — |
| Onchocerciasis | 14.650 million | Yes | Preclinical |
| Zika virus disease | 7.598 million | Yes | Phase 1–2 testing in endemic areas |
| Chagas disease | 7.201 million | Yes | Preclinical |
| Leishmaniasis | 4.835 million | Yes | Phase 1–2 testing in endemic areas |
| Trachoma | 3.338 million | No | — |
| Cysticercosis | 2.676 million | Yes | Veterinary transmission blocking vaccine |
| Cystic Echinococcosis | 0.974 million | Yes | Veterinary transmission blocking vaccine |
| Leprosy | 0.523 million | Yes | Preclinical |
| Yellow Fever | 0.112 million | Yes | Licensed vaccine |
| Rabies | 0.013 million | Yes | Licensed vaccine |
| African trypanosomiasis | 0.007 million | No | — |
| Ebola virus disease | 0.001 million | Yes | Pre-licensure |
| Guinea worm disease | 0.000 | No | — |