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. 2014 Apr 10;1(1):50–56. doi: 10.1002/mdc3.12014

Table 1.

Comparative pathology of IOH and PSP

IOH (Secondary, Other Than PAPT) PSP
Present Absent Present Absent
PAPT (present case) Present IOH;
↓ neurons in IO;
NFH with ballooning neurons;
dendritic enlargement with glomeruloid bodies;
residual bodies;
fibrillary astrocytosis with bizarre hypertrophic astrocytes;
tegmental gliosis;
IO hilar demyelination 		NFTs (tau positive);
symmetric IOH;
tightly packed tau‐positive granular intracellular lesions 		NFTs (tau positive);
tegmental gliosis;
IOH (cases with IOH);
↓ neurons in IO (cases with IOH);
NFH with ballooning neurons (cases with IOH);
dendritic enlargement with glomeruloid bodies;
residual bodies (cases with IOH);
fibrillary astrocytosis with bizarre hypertrophic astrocytes (cases with IOH) 		IOH (cases without IOH);
↓ neurons in IO (cases without IOH);
NFH with ballooning neurons (cases without IOH);
dendritic enlargement with glomeruloid bodies (cases without IOH);
residual bodies (cases without IOH);
fibrillary astrocytosis with bizarre hypertrophic astrocytes (cases without IOH);
tightly packed tau positive granular intracellular lesions
Absent Vacuoles;
asymmetric IOH;
dentate/CTT lesion 		N/A Supratentorial involvement;
nigral cell loss and gliosis;
GVD 		N/A

NFH, high‐molecular‐weight neurofilament isoform; N/A, not applicable; GVD, granulovacuolar degeneration.