Table 1.

Iron imaging studies in RLS

	Imaging Method	Cases/Controls	Outcome	Serum Ft
Allen et al.64	MRI (R2′)	5 vs. 5	↓ iron in SN and putamen in RLS patients	N/A
Earley et al.65	MRI (R2′)	22 early, 19 late onset, 39 controls	↓ iron in SN and putamen in RLS patients	Individuals with serum Ft <18 μg/L were excluded, between group differences not evaluated
Haba‐Rubio et al.66	MRI (R2′)	2 vs. 9	↓ iron in SN, red nucleus and putamen in hemochromatosis patients with RLS	N/A
Astrakas et al.67	MRI (T2)	25 vs. 12	↓ iron in SNpc and trend toward ↓ iron in caudate and dentate nucleus in patients with RLS	No difference between groups
Godau et al.69	MRI (T2) TCS	6 vs. 19	Multiregional brain iron deficiency in RLS patients	For RLS 174.8 ± 50.7 ng/mL; N/A for controls
Knake et al.63	MRI (T2*)	12 vs. 12	No differences in iron deposition between cases and controls in 12 brain regions	111.9 ± 63.4 vs. 124.7 ± 171.8 ng/mL
Margariti et al.68	MRI (T2)	11 versus 11	↑ iron in GP and STN in RLS patients	N/A
Rizzo et al.70	MRI (phase imaging)	15 versus 15	↓ iron in SN, thalamus, putamen, and pallidum of RLS patients	71 ± 45 versus 82 ± 48 ng/mL
Schmidauer et al.71	TCS	20 RLS versus 20 PD versus 20 controls	↓ iron in SN in RLS patients	For RLS 78.4 ± 16.9 ng/mL; N/A for PD and controls
Godau et al.72	TCS	49 versus 49	↓ iron in SN in RLS patients	N/A
Pedroso et al.73	TCS	30 individuals with RLS and either PD or Machado‐Joseph disease	↓ iron in SN correlates with RLS severity	N/A

N/A, not available.