Table 1. Invertebrate [3H]-IMI radioligand summary [Kd (nM), Hill value and Bmax (fmol/mg)].
Pest | Species | Kd (nM) | Bmax (fmol/mg) | nHa) | Reference |
---|---|---|---|---|---|
Hemipteran | Myzus persicae | 0.14 | 284 | 0.61 | 51 |
12.58 | 486 | ||||
0.85 | 65 | 0.75 | 60 | ||
7 | 260 | ||||
0.6 | 250 | 0.85 | 56 | ||
7.2 | 716 | ||||
0.083 | 100 | 0.78 | 11 | ||
1.7 | 298 | ||||
2.3 | 220 | 1b) | 60 | ||
Myzus persicae FRC | 4.14 | 2016 | 1 | 11 | |
Aphis craccivora | 0.8 | 226 | 0.77 | 56 | |
21 | 911 | ||||
0.4–1.6 | 45–97 | 0.65–0.75 | 60 | ||
7–15 | 96–156 | ||||
2.2 | 86 | 0.97b) | 60 | ||
Nephotettix cincticeps | 0.0043 | 33 | 0.67 | 51 | |
1.23 | 179 | ||||
Nilaparvata lugens | 0.0035 | 4.1 | not reported. | 64 | |
1.5 | 18.3 | ||||
Non-hemipteran | Periplaneta americana | 3.14 | 2140 | 1.01c) | 51 |
Lucilia sericata | 1.75 | 539 | 1.02d) | 51 | |
Drosophila melanogaster | 1.42 | 126 | 1.04 | 51 | |
2.2 | 1344 | 1.02d) | 60 | ||
2.5 | 1621 | 1b, d) | 60 | ||
2.4 | 560 | 0.99b, d) | 62 | ||
Musca domestica | 0.7 | 305 | 0.84d) | 55 | |
9 | 475 | ||||
5.4 | 428 | 98d) | 60 | ||
3.2 | 400 | 1.01b, d) | 60 | ||
1.2 | 853 | 0.99b, d) | 49 | ||
Manduca sexta | 1.3 | 150 | 0.99e) | 51 | |
Heliothis virescens | 1.51 | 134 | 0.92f) | 51 | |
Ctenocephalides felis | 4.82 | 369 | 0.95 | 51 | |
Locusta migratoria | 0.2 | 153 | 0.63g) | 56 | |
8.9 | 336 |
a) Whole body unless noted. b) Performed in the presence of Triton X-100. c) Head dissection, d) head enrichment, e) enriched brain, f) adult isolated head region and, g) head and thorax ganglia.