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. 2018 Sep 25;9(75):34090–34102. doi: 10.18632/oncotarget.26124

Figure 2. PDGFRs may be involved in the suppressive effects of various drugs on differentiation into cancer-associated fibroblasts (CAFs).

Figure 2

(A, B) ST2 cells were pre-treated with tranilast (100 μM), pirfenidone (0.2 mg/mL), or imatinib (10 μM) for 1 h and then stimulated with TGFβ (10 ng/mL) for 3 and 7 days. Quantitative RT-PCR analysis was performed to measure mRNA expression of αSMA (A) and TGFβ (B). Each bar represents the mean ± SD (N=3), *P < 0.05. (C, D) ST2 cells were pre-treated with cromoglicate (100 μM), bosutinib (100 nM), or dasatinib (10 nM) for 1 h and then stimulated with TGFβ for 3 and 7 days. Quantitative RT-PCR analysis was performed to measure mRNA expression of αSMA (C) and TGFβ (D). Each bar represents the mean ± SD (N=3).