Table 2. Downregulated genes of selected enriched gene ontology categories following irradiation of SJ-GBM2 cells are shown based on sets of statistically significant changes (P < 0.05).

Gene ontology group	P-value	Fold changes	Gene symbol	Gene description
Cell adhesion	4.90E-03	0.3390	CD33	CD33 molecule
		0.4851	EDIL3	EGF like repeats and discoidin domains 3
		0.3426	EPHA4	EPH receptor A4
		0.4796	F11R	F11 receptor
		0.0456	L1CAM	L1 cell adhesion molecule
		0.3634	SPOCK1	SPARC/osteonectin, cwcv and kazal like domains proteoglycan 1
		0.1247	TNFAIP6	TNF alpha induced protein 6
		0.3202	ALCAM	activated leukocyte cell adhesion molecule
		0.4053	ADGRB1	adhesion G protein-coupled receptor B1
		0.4680	BCAM	basal cell adhesion molecule (Lutheran blood group)
		0.1871	CDH3	cadherin 3
		0.3202	CDH8	cadherin 8
		0.4662	COL5A1	collagen type V alpha 1 chain
		0.2467	COL8A1	collagen type VIII alpha 1 chain
		0.0839	CNTN2	contactin 2
		0.1860	CNTN4	contactin 4
		0.4905	CNTNAP3	contactin associated protein-like 3
		0.4111	EMP2	epithelial membrane protein 2
		0.2666	FAP	fibroblast activation protein alpha
		0.3239	LGALS3BP	galectin 3 binding protein
		0.3272	ITGA11	integrin subunit alpha 11
		0.3245	ITGA9	integrin subunit alpha 9
		0.2359	LAMA3	laminin subunit alpha 3
		0.2795	PTPRK	protein tyrosine phosphatase, receptor type K
		0.1867	ROBO2	roundabout guidance receptor 2
		0.2710	TNC	tenascin C
Positive regulation of apoptotic process	1.30E-04	0.4109	AKAP13	A-kinase anchoring protein 13
		0.3966	DAB2IP	DAB2 interacting protein
		0.3180	FGD4	FYVE, RhoGEF and PH domain containing 4
		0.3340	KLF11	Kruppel like factor 11
		0.2253	ARHGEF16	Rho guanine nucleotide exchange factor 16
		0.1708	ARHGEF4	Rho guanine nucleotide exchange factor 4
		0.3533	TNFRSF8	TNF receptor superfamily member 8
		0.4738	ALDH1A2	aldehyde dehydrogenase 1 family member A2
		0.1373	EEF1A2	eukaryotic translation elongation factor 1 alpha 2
		0.4137	GAL	galanin and GMAP prepropeptide
		0.3390	ING2	inhibitor of growth family member 2
		0.2705	IFIT2	interferon induced protein with tetratricopeptide repeats 2
		0.4339	IRF5	interferon regulatory factor 5
		0.4589	JMY	junction mediating and regulatory protein, p53 cofactor
		0.0767	NGFR	nerve growth factor receptor
		0.0816	PNMA2	paraneoplastic Ma antigen 2
		0.3719	PAWR	pro-apoptotic WT1 regulator
		0.4911	STK3	serine/threonine kinase 3
Negative regulation of cell proliferation	4.10E-02	0.2946	CEBPA	CCAAT/enhancer binding protein alpha
		0.3390	CD33	CD33 molecule
		0.3966	DAB2IP	DAB2 interacting protein
		0.4179	DLC1	DLC1 Rho GTPase activating protein
		0.3340	KLF11	Kruppel like factor 11
		0.2957	RERG	RAS like estrogen regulated growth inhibitor
		0.3533	TNFRSF8	TNF receptor superfamily member 8
		0.4053	ADGRB1	adhesion G protein-coupled receptor B1
		0.4738	ALDH1A2	aldehyde dehydrogenase 1 family member A2
		0.4351	CHD5	chromodomain helicase DNA binding protein 5
		0.1004	F2R	coagulation factor II thrombin receptor
		0.3390	ING2	inhibitor of growth family member 2
		0.4605	IRF1	interferon regulatory factor 1
		0.4571	IL1B	interleukin 1 beta
		0.3036	LDOC1	leucine zipper down-regulated in cancer 1
		0.4785	LIF	leukemia inhibitory factor
		0.0953	MEG3	maternally expressed 3 (non-protein coding)
		0.2795	PTPRK	protein tyrosine phosphatase, receptor type K
		0.4911	STK3	serine/threonine kinase 3
		0.4718	SLIT3	slit guidance ligand 3
Protease binding	1.20E-03	0.0331	CD70	CD70 molecule
		0.1539	TIMP4	TIMP metallopeptidase inhibitor 4
		0.2020	A2M	alpha-2-macroglobulin
		0.2780	CSTA	cystatin A
		0.1772	CST6	cystatin E/M
		0.2666	FAP	fibroblast activation protein alpha
		0.4143	IL1R1	interleukin 1 receptor type 1
		0.1026	RYR1	ryanodine receptor 1
		0.2443	SERPINA1	serpin family A member 1
		0.3182	SERPINA5	serpin family A member 5
		0.4862	SERPINE1	serpin family E member 1

Experiments were performed in triplicate.