Table 1.
Comparisons of characteristics between diabetic patients with community-acquired KP bacteremia who developed invasive syndrome and those who did not develop invasive syndrome
| Characteristics, n (%) | Invasive syndrome (%)
|
P-valuea | |
|---|---|---|---|
| Yes (n=41) | No (n=134) | ||
|
| |||
| K1/K2 serotype of KP | 18 (43.9) | 4 (3.0) | <0.01b |
| Male | 17 (41.5) | 47 (35.1) | 0.47 |
| Age ≥60 years | 19 (46.3) | 65 (48.5) | 0.86 |
| Newly diagnosed diabetes | 8 (19.5) | 15 (11.2) | 0.19 |
| HbA1c ≤7% | 4 (9.8) | 29 (21.6) | 0.11 |
| HbA1c 7%–9% | 5 (12.2) | 32 (23.9) | 0.13 |
| HbA1c ≥9% | 32 (78.0) | 73 (54.4) | 0.01b |
| Cardiovascular diseases | 4 (9.8) | 4 (3.0) | 0.09 |
| Liver cirrhosis | 3 (7.3) | 5 (3.7) | 0.39 |
| Chronic renal failure | 8 (19.5) | 21 (15.7) | 0.64 |
| Alcoholism | 3 (7.3) | 6 (4.5) | 0.44 |
| COPD | 3 (7.3) | 6 (4.5) | 0.44 |
| Malignancy | 3 (7.3) | 13 (9.7) | 0.77 |
| Biliary tract diseases | 1 (2.4) | 4 (3.0) | >0.99 |
| High-dose steroid use | 3 (7.3) | 6 (4.5) | 0.44 |
| Aspirin use | 1 (2.4) | 23 (17.1) | 0.02b |
| Leukocytes, ×109/Lc | 12.2 (4.4) | 10.4 (4.4) | 0.75 |
| Platelets, ×109/Lc | 178 (45) | 202 (57) | 0.87 |
| C-reactive protein, mg/Lc | 163 (97) | 166 (85) | 0.83 |
Notes:
There was adequate goodness of fit (Hosmer and Lemeshow test: χ2=0.50, P>0.99). ROC analysis indicated that the predictive performance of the logistic regression model was adequate (AUC=0.77).
Results of multivariate analysis indicated that diabetic patients with community-acquired KP bacteremia who were infected with strains expressing the K1/K2 serotype (AOR, 8.81; 95% CI, 2.18–35.53; P<0.01) and those with HbA1c ≥9% (AOR, 4.97; 95% CI, 1.73–14.23; P<0.01) were at increased risk of developing IKLAS, whereas those who had recent therapy with aspirin (AOR, 0.17; 95% CI, 0.04–0.79; P=0.02) were at a lower risk of acquiring IKLAS.
Data depicted are mean values with SD.
Abbreviations: KP, Klebsiella pneumonia; ROC, receiver operating characteristic; AUC, area under the curve; AOR, adjusted odds ratio; IKLAS, invasive Klebsiella pneumoniae liver abscess syndrome.