Table 2.

Multivariate survival analysis for evaluating the prognostic score on gastric cancer cause-specific survival in SEER database

Variable	N	5-year CCS (%)	Multivariate analysis
			HR (95% CI)	P-value
Years of diagnosis				<0.001
1988–1992	2,339	44.8	Reference
1993–1997	3,575	47.2	0.929 (0.864–0.998)	0.044
1998–2002	5,709	50.0	0.928 (0.868–0.993)	0.030
2003–2007	7,425	55.3	0.871 (0.815–0.930)	<0.001
2008–2012	7,043	61.0	0.808 (0.754–0.867)	<0.001
Sex				<0.001
Male	16,663	51.8	Reference
Female	9,428	56.1	0.874 (0.838–0.910)
Race				<0.001
White	17,457	51.2	Reference	<0.001
Black	3,203	52.1	0.979 (0.924–1.037)	0.468
Othera	5,431	60.8	0.789 (0.735–0.839)	<0.001
Histotype				0.713
Adenocarcinoma	20,274	54.7	Reference
Mucinous	971	47.8	0.996 (0.907–1.093)	0.925
Signet ring cell	4,846	49.0	1.019 (0.973–1.069)	0.422
TNM stage				<0.001
IA	4,303	87.7	Reference
IB	2,718	76.5	1.691 (1.512–1.890)	<0.001
IIA	3,782	66.0	2.401 (2.174–2.652)	<0.001
IIB	3,312	51.8	3.740 (3.395–4.120)	<0.001
IIIA	5,002	41.2	4.895 (4.468–5.363)	<0.001
IIIB	4,749	26.6	7.165 (6.540–7.848)	<0.001
IIIC	2,225	13.5	10.607 (9.611–11.706)	<0.001
Marital status				<0.001
Married	16,308	54.0	Reference
Unmarried	9,783	52.5	1.142 (1.097–1.189)
Score				<0.001
1	608	82.2	Reference
2	2,715	71.4	1.389 (1.144–1.686)	0.001
3	6,165	62.0	1.521 (1.263–1.833)	<0.001
4	8,224	51.1	1.717 (1.427–2.066)	<0.001
5	5,998	41.6	1.932 (1.603–2.327)	<0.001
6	2,381	35.5	2.201 (1.818–2.665)	<0.001

Note:

^aOther includes American Indian/Alaska native, Asian/Pacific Islander, and unknown.

Abbreviation: SEER, Surveillance, Epidemiology, and End Results.