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. 2018 Oct 8;10:4311–4323. doi: 10.2147/CMAR.S173496

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© 2018 Zhang and Zhang. This work is published and licensed by Dove Medical Press Limited

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Potential mechanisms underlying the effects of NUDT21 on K562 cell growth.

Notes: (A) The protein levels of p-ERK1/2 and PTEN were shown in K562 cells transfected with shRNA control or NUDT21 shRNA using Western blot analysis. (B) The mRNA levels of PTEN were compared between K562 cells of shRNA control group and NUDT21 shRNA group using qRT-PCR analysis. (C) BrdU incorporation in K562 cells treated with honokiol or control. (D) Percentages of cells undergoing apoptosis (annexin V-positive) in different groups were shown. Data are expressed as mean ± SD for duplicate experiments. ^*P<0.05; ^**P<0.01; ^***P<0.001.

Abbreviations: BrdU, bromodeoxyuridine; PI, propidium iodide; PTEN, phosphatase and tensin homolog deleted on chromosome 10; qRT-PCR, quantitative reverse polymerase chain reaction.