Key resources table.

Reagent type (species) or resource	Designation	Source or reference	Identifiers	Additional information
Cell line (H. sapiens)	CCL2	ATCC Cat# CCL-2, RRID:CVCL_0030	Authentication through Genetica Cell Line Testing	Authenticated by STR profiling
Antibody	Anti PERK	Cell Signaling technology	CST C33E10, RRID:AB_2095847	(1:2000)
Antibody	anti-Phospho- PERK	Cell Signaling Technology	CST 3179S, RRID:AB_2095853	(1:2000)
Antibody	anti-P-eIF2alpha	Cell Signaling Technology	CST 9721S, RRID:AB_330951	(1:2000)
Antibody	Anti- β- Actin	Cell Signaling Technology	CST 4967S, RRID:AB_330288	(1:5000)
Antibody	anti Oxidative Stress Markers	Abcam	Ab179843, RRID:AB_2716714	(1:1000)
Other	CM-H2DCFDA	Thermo Fisher S cientific	C6827	10 μM
Sequence-based reagent	RPL19_ F 5'-ATGTATCACAGCCTGTACCTG-3'; RPL19_ R 5'- TTCTTGGTCTCTTCCTCCTTG-3'	PMID: 19137072
Sequence-based reagent	sXBP1 forward 5′ TGCTGAGTCCGCAGCAGGTG-3′; reverse 5’-GCTGGCAGGCTCTGGGGAAG-3’)	PMID: 22038282
Commercial assay or kit	Pierce Quantitative Colorimetric Peptide Assay	Thermo Fisher Scientific	23275
Commercial assay or kit	SuperScript III First-Strand Synthesis System	Thermo Fisher Scientific	18080051
Commercial assay or kit	KAPA SYBR FAST qPCR Master Mix (2X) Kit	Kapa Biosystem	KR0389 – v10.16
Commercial assay or kit	TMT 10plex	Sigma-Aldrich	90110
Commercial assay or kit	Plasmotest	InvivoGen	rep-pt1
Commercial assay or kit	Universal Mycoplasma Detection Kit ATCC	ATCC	30–1012K
Chemical compound, drug	Hydrogen Peroxide	Sigma-Aldrich	216763
Chemical compound, drug	Tunicamycin	Sigma-Aldrich	T7765
Chemical compound, drug	2,2,2-Trifluoroethanol	Sigma-Aldrich	T8132
Chemical compound, drug	Iodoacetamide	Sigma-Aldrich	I6709
Software, algorithm	Maxquant (1.5.5.1)	PMID: 19029910	RRID:SCR_014485
Software, algorithm	PECAplus	PMID: 24229407, 29263799	https://github.com/PECAplus