FFig. 1.
—Outline of the method. (a) Sequencing data generated from samples with different sequencing quality or processing might introduce different errors (black dots). Since these errors will be present in samples coming from the same platform, they will give a signal of linkage between different chromosomes (dashed lines). (b) The contribution to the linkage signal can be computed for each sample (dashed lines), and used to identify samples coming from the same batch and with similar error profiles, as well as the errors. See also supplementary figure 1, Supplementary Material online.