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. Author manuscript; available in PMC: 2019 Apr 12.
Published in final edited form as: Science. 2018 Sep 6;362(6411):236–239. doi: 10.1126/science.aau5138

Fig. 1. Bioinformatic approach for discovering Acr genes.

Fig. 1.

(A) Anti-CRISPRs allow survival of cells containing self-targeting CRISPR arrays. (B) STSS finds self-targeting CRISPR spacers in genomic DNA, predicts the type of CRISPR system involved, and obtains information about the targeted sequence. (C) A large percentage of genomes containing self-targeting (ST) spacers predicted to be lethal contain previously-identified Acr genes. (D) Moraxella bovoculi strain 22581 contains three self-targeting spacers in two different prophages in the genome. All of the protospacers contain a TTV protospacer-adjacent motif (PAM) (22).