Table 4.

Association between ventricular function and pulmonary hypertension with PICU mortality and probability of extubation for patients not exposed to iNO at the time of echocardiogram. Both models adjusted for Worst OI in the first 24 hours after PARDS diagnosis and PRISM III score at 12 hours (n=72).

Echo findings within 24 hours of PARDS diagnosis	PICU mortality		Probability of extubation
	OR (95% CI)	p value	SHR (95% CI)	p value
RV FAC < 35%	0.94 (0.21 to 04.21)	0.940	0.97 (0.49 to 1.93)	0.939
RV GLS < −2SD	4.11 (1.10 to 15.30)	0.035	0.45 (0.23 to 0.88)	0.020
RV FWS < −2SD	2.00 (0.56 to 7.10)	0.285	0.63 (0.34 to 1.14)	0.128
TAPSE z-score < −2SD	1.27 (0.33 to 4.79)	0.729	0.77 (0.43 to 1.37)	0.378
Evidence of PH	1.30 (0.29 to 5.78)	0.735	0.49 (0.27 to 0.99)	0.047
LV FS < 28%	1.76 (0.47 to 6.66)	0.404	0.78 (0.35 to 1.77)	0.557

OR = odds ratio; SHR: Subdistribution hazard ratio; SD = standard deviation; RV = right ventricle; FAC = fractional area change; GLS = global longitudinal strain; FWS = free wall strain; TAPSE = tricuspid annular peak systolic excursion; PH = pulmonary hypertension, LV = left ventricle; FS = fractional shortening