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. Author manuscript; available in PMC: 2019 Nov 1.
Published in final edited form as: Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2018 May 24;10(6):e1522. doi: 10.1002/wnan.1522

Figure 9. Increasing multiplexing and screening capacity of droplet platforms.

Figure 9

(A) A droplet-on-demand system was developed to interface droplet chips with off-chip reservoirs in order to construct libraries of droplets with controllable input concentrations of sample/reagents and controllable volumes at 30 Hz. (Reproduced from (Churski et al., 2010) with permission of The Royal Society of Chemistry.) (B) A device was developed to facilitate the transition of nanoliter plugs that were constructed with controlled combinations of sample/reagents, into picoliter droplets without compromising droplet stability and uniformity. (Copyright 2017 IEEE. Reprinted, with permission, from (P. Zhang et al., 2017)) (C) A serial sample loading (SSL) system was developed to interface droplet platforms with conventional 96-well plates to facilitate automated sample and reagent loading. (Reproduced from (T. D. Rane et al., 2012) with permission of Sage Publishing.)