Table 1.
Demographic and clinical characteristics of study subjects
| Clinical presentation & initial clinical diagnoses* | In vivo MRI | Pathology | MRI-path intervals (mths) | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| ID | Date (m/y) | Age (y) | Gender | DOI (y)**** | Date (m/y) | Path. Diagn. | SN | |||
| Syn | Tau | |||||||||
| 1 | Diagnosed with PD in 1993 after 2 y of PS** | 01/2013 | 68 | F | 22 | 01/2013 | PD | 1 | 1 | 0 |
| 2 | Diagnosed with PD in 2009 after 2 y history of PS & falls | 01/2013 | 91 | M | 4 | 10/2013 | PSP | 1 | 3 | 9 |
| 3 | Diagnosed with MSA in 2010 after 3 y of PS & falls | 02/2013 | 63 | M | 6 | 03/2014 | MSA | 1 | 1 | 13 |
| 4 | Diagnosed with PSP in 2005 after 3 y of PS & imbalance | 03/2013 | 83 | M | 8 | 05/2014 | PD | 1 | 0 | 14 |
| 5 | Diagnosed with PD in 2002 after 2 y of PS | 10/2013 | 78 | F | 11 | 07/2014 | DLB | 1 | 2 | 9 |
| 6 | Diagnosed with PD in 2006 after 1 y of PS & slurry speech | 10/2013 | 74 | M | 9 | 10/2014 | PSP | 0 | 2 | 12 |
| 7 | Diagnosed with MSA in 2006 after 4 y cognitive decline, PS, & autonomic dysfunction | 04/2013 | 78 | M | 9 | 01/2015 | PD | 1 | 1 | 21 |
| 8 | Diagnosed with PD in 2006 after 5 y PS and 1 y of cognitive complaints | 10/2013 | 75 | M | 9 | 02/2015 | DLB | 1 | 1 | 16 |
| 9 | Diagnosed as MSA in 2011 after 2 y of PS, imbalance, anosmia, and sleep disorder | 06/2014 | 82 | M | 5 | 02/2015 | PSP | 0 | 3 | 8 |
| 10 | Spouse of a patient, had diabetes, hypertension, & neuropathy | 03/2013 | 70 | M | na | 08/2015 | Mild brain atrophy | 0 | 0 | 29 |
| 11 | Diagnosed with PD in 2007 after 3 y PS & cognitive complaints | 02/2014 | 78 | M | 7 | 02/2016 | DLB | 1 | 2 | 24 |
| 12 | Suspected PSP in 2015 after 2 y of backward falling, 20 y of ET | 06/2015 | 83 | F | na | 07/2016 | Mild AD | 0 | 0 | 13 |
| 13 | Diagnosed with PD in 1994 within 1 y of PS | 07/2014 | 69 | M | 20 | 07/2016 | PD | 1 | 0 | 24 |
| 14 | Diagnosed with PD after 2 y of PS | 01/2013 | 73 | M | 3 | 10/2016 | CBG | 0 | 3 | 47 |
Diagnoses were based on the impression of the first neurologist who evaluated the patient for the concerning symptoms. Neurologist may or may not have been a movement disorder specialist.
Parkinsonian symptoms (PS) are defined as bradykinesia, and rest tremor or rigidity;
Abbreviations: AD: Alzheimer’s disease; CBD: Cortical basal degeneration; Diag, Diagnosis; DOI: Duration of illness; DLB: Diffuse Lewy Body Disease; ET: essential tremor; F: Female; M: Male; MSA: multiple system atrophy; mths: months; PD: Parkinson’s disease; PS: parkinsonian symptoms that are defined as bradykinesia, and rest tremor or rigidity; PSP: progressive supranuclear palsy; SN: substantial nigra; Syn: α-synuclein; y: years.